Encapsulation of bioactive fermented wheat (Lisosan G) in Eudragit-liposomes

Liposomes are one of the most studied and promising nanocarriers to date, representing a biocompatible, safe, efficient delivery system for both hydrophilic lipophilic compounds. This work aimed evaluate efficacy in encapsulating an aqueous extract Lisosan G (LG), Triticum aestivum whole grains fermented powder with strong antioxidant activity, into Eudragit-liposomes designed oral delivery. The total phenolics activity LG encapsulated were evaluated by Folin-Ciocalteu, DPPH, FRAP colorimetric assays. Finally, biological formulations was assessed as human erythrocytes protection from oxidative stress through cellular (CAA) assay. Our results demonstrate that encapsulation preserved content retained its properties vitro ex vivo. Furthermore, exhibited increased ferric reducing capacity insult, probably due liposome constituents. Therefore, represents excellent strategy prevent possible reduction loss bioactive compounds, deliver them via administration.